ceesdekker.net Secrets
ceesdekker.net Secrets
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate pursuits incorporate:
It had been only during the nineties nevertheless, when nanotechnology had Highly developed to some amount the place one molecules might be manipulated, that the 1st experimental gadgets started to look.
Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I
Our get the job done was promptly adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors created from solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. Inside of just a few months, we have been able to evaluate transportation as a result of someone single-walled carbon nanotube. Based upon reduced-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Technological know-how using an Lively study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes had been authentic quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
‘In the beginning we checked out Organic methods by using a Actual physical view and acted on the basis of your tools we understood. It took a several years right before we began Doing work additional on the massive Organic problems. I then started to phone it nanobiology, a expression that didn't exist at some time.
2011, initial in vitro measurements of transport throughout one biomimetic nuclear pore intricate; growth of multiplexed magnetic ceesdekker tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
‘You should not just think about the thoughts of tomorrow, and also take into account the queries from the working day soon after tomorrow’
Bulk-surface area coupling identifies the mechanistic connection between Min-protein patterns in vivo As well as in vitro
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)